CD10+ is 52 - 68% sensitive and > 95% specific with canalicular pattern (Am J Surg Pathol 2001;25:1297, Am J Surg Pathol 2002;26:978), although another study recommends use of HepPar1, MOC31 and pCEA, but not CD10 (Mod Pathol 2002;15:1279) Kidney.

How Is It Tested?

CD3 / CD20 immunostains are often performed in initial cytological evaluation of lymphoid-rich pleural effusions, but their cost-effectiveness has been questioned (Diagn Cytopathol 2012;40:565) Does NOT improve detection of gluten sensitive enteropathy when H&E sections are normal. The initial immunohistochemical panel for lymphomas would include CD20 (B-cells), CD3 (T-cells), CD138 (plasma cells) and CD30 (Reed-Sternberg cells of classical Hodgkin lymphoma (cHL), anaplastic B- and T-cell lymphomas.) CD20 can be used to tell the difference between these two cancers in that test results for CD20 would usually be positive in the case of DLBCL but negative for ALCL. CD30: lymphocyte activation antigen important in diagnosis of classic Hodgkin's lymphoma, anaplastic large cell lymphoma and embryonal carcinoma CD30v: variant form of CD30 which retains only the cytoplasmic domain; very little has been published about CD30v Note: all content of this topic is about CD30, unless stated otherwise Terminology. (Mod Pathol 2013;26:1241) Microscopic (histologic) images.

Common B cell marker (also CD20, CD79a, PAX5) Expressed by B cells and follicular dendritic cells Early B lineage-restricted antigen present on most pre-B cells, B-ALL and B-CLL cells (OMIM #107265) Pathophysiology . … A special technique called immunohistochemistry (IHC) is used to identify CD20 and determine whether an abnormal cancerous white blood cell (lymphocyte in particular) is a B-cell or T-cell.

Multiple antibodies are then utilized for subtyping the B- and T-cell lymphomas to make a specific diagnosis. Distinguish renal cell carcinoma, clear cell type, eosinophilic variant (CD10+) from chromophobe carcinoma, eosinophilic variant or …

Also known as Ki-1, Ber-H2 Pathophysiology. Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells Regulates B cell development, activation and differentiation (J Immunol …

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